Regulatory & Compliance Incidents-Non-compliance observed during self-inspection or regulatory audits

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Incident Report No.: IR/QA/2025/051
Incident Raised By: (Name, Sign & Date)
Department: Quality Assurance
Date of Incident: 29-Aug-2025
Time: 12:30 PM

Category: ☑ Quality Impacting Incidents ☐ Quality Non-Impacting Incidents


(SECTION I) Description of the Incident:

During internal self-inspection on 28-Aug-2025, it was observed that in the granulation area, the equipment cleaning logbook was not updated for the last two cleaning activities (dated 25-Aug-2025 and 26-Aug-2025). The deviation was noted by QA inspector and categorized as a documentation non-compliance.

Additionally, a similar observation was highlighted by a regulatory auditor during a previous audit, where the inspector stressed on real-time documentation practices.


(SECTION II) Immediate Action:

  • QA instructed production staff to immediately update the cleaning record with proper details.
  • Granulation equipment was verified physically to be in clean condition by QA.
  • Area was allowed to continue operation only after compliance verification.

Action Taken By: QA Officer (Name, Sign & Date)
Action Checked By: QA Head (Name, Sign & Date)


Preliminary Investigation (Root Cause for Incident):

  • Operator failed to record cleaning activity in real time due to workload and shift change.
  • Inadequate awareness of importance of contemporaneous documentation.
  • Lack of supervisory check on logbook entries.

Department Head: (Sign, Date & Name)


(SECTION III) Classification of Errors / Events responsible for Incident:

☐ Breakdown of an Equipment / Instrument / Utility Machine
☐ Malfunctioning of an Equipment / Instrument / Utility Machine
☐ Power Failure
☑ Documentation Error
☑ Human Error
☐ Others


(SECTION IV) Suggested Corrective Action & Preventive Action To Be Taken:

Corrective Action:

  • Missing entries completed with proper annotation (“Late Entry”) along with justification and signatures.
  • QA verified physical status of equipment before approving continuation of batch.

Preventive Action:

  • Retrain all production staff on GMP principles and ALCOA+ (Attributable, Legible, Contemporaneous, Original, Accurate) documentation practices.
  • Implement checklist-based supervisory review of logbooks at the end of each shift.
  • Evaluate feasibility of electronic logbook system (ERP integration) to minimize manual errors.

Responsible Staff: QA Officer & Production Supervisor
Target Date for Completion: 20-Sep-2025

Suggested By: QA Head (Sign, Date & Name)
Reviewed By: Plant Head (Sign, Date & Name)


(SECTION V) Evaluation and Recommendation by QA / VP Technical:

  • Observation categorized as regulatory risk, as repeated lapses may attract critical audit finding.
  • Recommend periodic internal audits with stricter follow-ups on CAPA implementation.
  • This case to be used as training example for all staff on importance of contemporaneous documentation.

Q.A. Head / VP Technical: (Sign, Date & Name)


(SECTION VI) Compliance of the Recommendations and Closure:

Verification Done By:

  • Department Head (Sign, Date & Name)
  • QA Head / VP Technical (Sign, Date & Name)

Final Conclusion with Estimated Commercial Loss:
No direct material loss; however, risk of regulatory action in case of repeat non-compliance.
Remarks: Incident Closed after CAPA implementation.

Head of Quality Assurance Department / VP Technical: (Sign, Date & Name)

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